Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis.

ABSTRACT:

Background

Preterm infants requiring assisted ventilation are at significant risk of both pulmonary and cerebral injury. Inhaled Nitric Oxide, an effective therapy for pulmonary hypertension and hypoxic respiratory failure in the full term infant, has also been studied in preterm infants. The most recent Cochrane review of preterm infants includes 11 studies and 3,370 participants. The results show a statistically significant reduction in the combined outcome of death or chronic lung disease (CLD) in two studies with routine use of iNO in intubated preterm infants. However, uncertainty remains as a larger study (Kinsella 2006) showed no significant benefit for iNO for this combined outcome. Also, trials that included very ill infants do not demonstrate significant benefit. One tria

SUBMITTER: Askie LM 

PROVIDER: S-EPMC2860486 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature