LPA and PLG sequence variation and kringle IV-2 copy number in two populations.

ABSTRACT:

Background/aims

Lp(a) levels have long been recognized as a potential risk factor for coronary heart disease that is almost completely under genetic control. Much of the genetics impacting Lp(a) levels has been attributed to the highly polymorphic LPA kringle IV-2 copy number variant, and most of the variance in Lp(a) levels in populations of European-descent is inversely correlated with kringle IV copy number. However, less of the variance is explained in African-descent populations for the same structural variation. African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations.

Methods

To identify potential cis-acting factors, we re-sequenced the gene LPA for single nucleotide

SUBMITTER: Crawford DC 

PROVIDER: S-EPMC2861532 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature