High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2.

ABSTRACT: MicroRNAs (miRNAs) are noncoding RNAs that regulate global gene expression. miRNAs often act synergistically to repress target genes, and their dysregulation can contribute to the initiation and progression of a variety of cancers. The clinical relationship between global expression of miRNA and mRNA in cancer has not been studied in detail. We used whole-genome microarray analyses of CD138-enriched plasma cells from 52 newly diagnosed cases of multiple myeloma to correlate miRNA expression profiles with a validated mRNA-based risk stratification score, proliferation index, and predefined gene sets. In stark contrast to mRNAs, we discovered that all tested miRNAs were significantly up-regulated in high-risk disease as defined by a validated 70-gene risk score (P < 0.01) and proliferation i

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC2867889 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature