Ontology highlight
ABSTRACT:
SUBMITTER: Noushmehr H
PROVIDER: S-EPMC2872684 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Cancer cell 20100415 5
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display dist ...[more]