Reduced arteriovenous shunting capacity after local heating and redistribution of baseline skin blood flow in type 2 diabetes assessed with velocity-resolved quantitative laser Doppler flowmetry.

ABSTRACT:

Objective

To compare the microcirculatory velocity distribution in type 2 diabetic patients and nondiabetic control subjects at baseline and after local heating.

Research design and methods

The skin blood flow response to local heating (44 degrees C for 20 min) was assessed in 28 diabetic patients and 29 control subjects using a new velocity-resolved quantitative laser Doppler flowmetry technique (qLDF). The qLDF estimates erythrocyte (RBC) perfusion (velocity x concentration), in a physiologically relevant unit (grams RBC per 100 g tissue x millimeters per second) in a fixed output volume, separated into three velocity regions: v <1 mm/s, v 1-10 mm/s, and v >10 mm/s.

Results

The increased blood flow occurs in vessels with a velocity >1 mm/s. A significantly lower res

SUBMITTER: Fredriksson I 

PROVIDER: S-EPMC2889755 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature