PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARgamma deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand the impact of airspace enlargement in conditionally targeted mice upon the physio-mechanical properties of the lung.

Methods

We measured elastic recoil and its determinants, including tissue structure and surface forces. We measured alveolar number using radial alveolar counts, and airspace sizes and their distribution using computer-assisted morphometry.

Results

Air vs. saline-filled pressure volume profiles demon

SUBMITTER: Simon DM 

PROVIDER: S-EPMC2889874 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature