Anopheles gambiae PRS1 modulates Plasmodium development at both midgut and salivary gland steps.

ABSTRACT:

Background

Invasion of the mosquito salivary glands by Plasmodium is a critical step for malaria transmission. From a SAGE analysis, we previously identified several genes whose expression in salivary glands was regulated coincident with sporozoite invasion of salivary glands. To get insights into the consequences of these salivary gland responses, here we have studied one of the genes, PRS1 (Plasmodium responsive salivary 1), whose expression was upregulated in infected glands, using immunolocalization and functional inactivation approaches.

Methodology/principal findings

PRS1 belongs to a novel insect superfamily of genes encoding proteins with DM9 repeat motifs of uncharacterized function. We show that PRS1 is induced in response to Plasmodium, not only in the salivary gl

SUBMITTER: Chertemps T 

PROVIDER: S-EPMC2902509 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature