Translational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection.

ABSTRACT:

Background

Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors. Malaria parasites in the midgut are surrounded by a hostile environment rich in digestive enzymes, while a rapidly responding immune system recognizes Plasmodium ookinetes and recruits killing factors from the midgut and surrounding tissues, dramatically reducing the population of invading ookinetes before they can successfully traverse the midgut epithelium. Understanding molecular details of the parasite-vector interactions requires precise measurement of nascent protein synthesis in the mosquito during Plasmodium infection. Current expression profiling primarily m

SUBMITTER: Mead EA 

PROVIDER: S-EPMC3443010 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature