Ontology highlight
ABSTRACT:
SUBMITTER: Kuchen S
PROVIDER: S-EPMC2909788 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Immunity 20100603 6
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We applied miRNA-, mRNA-, and ChIP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome and epigenome. We show that lymphocyte-specific miRNAs are either tightly controlled by polycomb group-mediated H3K27me3 or maintained in a semi-activated epigenetic state prior to full expression. Because of miRNA ...[more]