Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset disease.

ABSTRACT:

Background & aims

The influence of age on the presentation, clinical course, and therapeutic response of patients with adult-onset ulcerative colitis (UC) is understudied. Given potential age-related differences in risk factors and immune function, we sought to determine if disease behavior or clinical outcomes differed between patients diagnosed with UC in later versus earlier stages of adulthood.

Methods

We performed a retrospective cohort study of 295 patients with UC seen at a tertiary care center from 2001 to 2008. Adult subjects newly diagnosed with UC between the ages of 18 and 30 years were defined as early onset, those newly diagnosed at age 50 or older were defined as late onset. The 2 groups were analyzed for differences in medication use and clinical end points,

SUBMITTER: Ha CY 

PROVIDER: S-EPMC2914180 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature