Ulcerative colitis: Impact of early disease clearance on long-term outcomes - A multicenter cohort study.

ABSTRACT:

Background

Clinical remission and endoscopic mucosal healing are the main treatment targets in patients with ulcerative colitis (UC). Recently, the concept of disease clearance has been proposed as a potential target in UC.

Objective

We aimed to evaluate the impact of disease clearance on long-term outcomes in UC patients.

Methods

A multicenter retrospective cohort study was conducted at the Humanitas Research Hospital-IRCCS (Italy) and at the Nancy University Hospital (France) between 2014 and 2021. Disease clearance in UC was defined as simultaneous clinical (partial-Mayo score ≤2), endoscopic (endoscopic-Mayo score = 0), and histological (Nancy index = 0) remission, and patients were monitored over a long-time follow-up (≥12 months), to compare the occurrence of ne

SUBMITTER: D'Amico F 

PROVIDER: S-EPMC9486490 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature