Th17, gut, and HIV: therapeutic implications.

ABSTRACT:

Purpose of review

The purpose of this review is to discuss the apparent impact of persistent-immune activation and inflammation on morbidity and mortality among treated HIV-infected individuals, to explore the potential role of Th17 T-cell depletion in this process, and to discuss potential-therapeutic implications.

Recent findings

Although the vast majority of HIV-infected individuals can now achieve and maintain viral suppression with modern-antiretroviral therapy (ART), their life expectancy remains much shorter than the general population and they continue to be at much higher risk for non-AIDS-associated diseases commonly associated with aging (non-AIDS-associated cancer, cardiovascular disease, etc). Abnormal levels of immune activation and inflammation persist despite

SUBMITTER: Hunt PW 

PROVIDER: S-EPMC2917631 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature