Ontology highlight
ABSTRACT:
SUBMITTER: Marasa BS
PROVIDER: S-EPMC2919253 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Aging 20100601 6
MicroRNAs (miRNAs) are short non-coding RNAs that regulate diverse biological processes by controlling the pattern of expressed proteins. In mammalian cells, miRNAs partially complement their target sequences leading to mRNA degradation and/or decreased mRNA translation. Here, we have analyzed transcriptome-wide changes in miRNAs in senescent relative to early-passage WI-38 human diploid fibroblasts (HDFs). Among the miRNAs downregulated with senescence were members of the let-7 family, while up ...[more]