Ontology highlight
ABSTRACT:
SUBMITTER: Rathinakumar R
PROVIDER: S-EPMC2923358 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rathinakumar Ramesh R Wimley William C WC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100421 9
Membrane-permeabilizing peptide antibiotics are an underutilized weapon in the battle against drug-resistant microorganisms. This is true, in part, because of the bottleneck caused by the lack of explicit design principles and the paucity of simple high-throughput methods for selection. In this work, we characterize the requirements for broad-spectrum antimicrobial activity by membrane permeabilization and find that different microbial membranes have very different susceptibilities to permeabili ...[more]