Nitro-oleic acid inhibits angiotensin II-induced hypertension.

ABSTRACT:

Rationale

Nitro-oleic acid (OA-NO(2)) is a bioactive, nitric-oxide derived fatty acid with physiologically relevant vasculoprotective properties in vivo. OA-NO(2) exerts cell signaling actions as a result of its strong electrophilic nature and mediates pleiotropic cell responses in the vasculature.

Objective

The present study sought to investigate the protective role of OA-NO(2) in angiotensin (Ang) II-induced hypertension.

Methods and results

We show that systemic administration of OA-NO(2) results in a sustained reduction of Ang II-induced hypertension in mice and exerts a significant blood pressure lowering effect on preexisting hypertension established by Ang II infusion. OA-NO(2) significantly inhibits Ang II contractile response as compared to oleic acid (OA) in

SUBMITTER: Zhang J 

PROVIDER: S-EPMC2937264 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature