International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.
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ABSTRACT: Purpose
To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.Materials and methods
Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.Results
Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.Conclusion
These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used.
SUBMITTER: Kirk P
PROVIDER: S-EPMC2946327 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.
Kirk Paul P He Taigang T Anderson Lisa J LJ Roughton Michael M Tanner Mark A MA Lam Wynnie W M WW Au Wing Y WY Chu Winnie C W WC Chan Godfrey G Galanello Renzo R Matta Gildo G Fogel Mark M Cohen Alan R AR Tan Ru San RS Chen Kevin K Ng Ivy I Lai Angie A Fucharoen Suthat S Laothamata Jiraporn J Chuncharunee Suporn S Jongjirasiri Sutipong S Firmin David N DN Smith Gillian C GC Pennell Dudley J DJ
Journal of magnetic resonance imaging : JMRI 20100801 2
<h4>Purpose</h4>To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.<h4>Materials and methods</h4>Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was als ...[more]
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