Low allergenic potential with fondaparinux: results of a prospective investigation.

ABSTRACT:

Objective

To determine the incidence and causes of skin reactions to the synthetic pentasaccharide fondaparinux.

Patients and methods

Patients who received prophylactic/therapeutic subcutaneous fondaparinux treatment for more than 7 days were prospectively examined for cutaneous adverse effects between September 1, 2008, and April 30, 2009. When indicated, other procedures, such as skin biopsy, allergy testing, and clinical/laboratory assessment for thrombosis and heparin-induced thrombocytopenia, were performed.

Results

Overall, 231 patients were enrolled. No patient developed typical delayed type IV hypersensitivity (DTH) erythematous skin lesions. However, one female patient experienced abdominal pruritus at sites of injection. Histology revealed a mild lymphohisti

SUBMITTER: Schindewolf M 

PROVIDER: S-EPMC2947963 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature