Ontology highlight
ABSTRACT:
SUBMITTER: Schutz P
PROVIDER: S-EPMC2948006 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
PloS one 20100930 9
DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1 ...[more]