Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder.

ABSTRACT:

Context

Just as typical development of anatomical asymmetries in the human brain has been linked with normal lateralization of motor and cognitive functions, disruption of asymmetry has been implicated in the pathogenesis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). No study has examined the development of cortical asymmetry using longitudinal neuroanatomical data.

Objective

To delineate the development of cortical asymmetry in children with and without ADHD.

Design

Longitudinal study.

Setting

Government Clinical Research Institute.

Participants

A total of 218 children with ADHD and 358 typically developing children, from whom 1133 neuroanatomical magnetic resonance images were acquired prospectively.

Main o

SUBMITTER: Shaw P 

PROVIDER: S-EPMC2948210 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature