Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty.

ABSTRACT:

Objective

To determine whether preoperative and/or postoperative central endothelial cell density (ECD) and its rate of decline postoperatively are predictive of graft failure caused by endothelial decompensation following penetrating keratoplasty to treat a moderate-risk condition, principally, Fuchs dystrophy or pseudophakic corneal edema.

Methods

In a subset of Cornea Donor Study participants, a central reading center determined preoperative and postoperative ECD from available specular images for 17 grafts that failed because of endothelial decompensation and 483 grafts that did not fail.

Results

Preoperative ECD was not predictive of graft failure caused by endothelial decompensation (P = .91). However, the 6-month ECD was predictive of subsequent failure (P < .0

SUBMITTER: Lass JH 

PROVIDER: S-EPMC2950322 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature