IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques.

ABSTRACT: Type III/lambda interferons (IFNs) were discovered less than a decade ago and are still in the process of being characterized. Although previous studies have focused on the function of IFN-lambda 3 (also known as interleukin (IL)-28B) in a small animal model, it is unknown whether these functions would translate to a larger, more relevant model. Thus in the present study, we have used DNA vaccination as a method of studying the influence of IFN-lambda 3 on adaptive immune responses in rhesus macaques. Results of our study show for the first time that IFN-lambda 3 has significant influence on antigen-specific CD8(+) T-cell function, especially in regards to cytotoxicity. Peripheral CD8(+) T cells from animals that were administered IFN-lambda 3 showed substantially increased cytotoxic respo

SUBMITTER: Morrow MP 

PROVIDER: S-EPMC2956930 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature