Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations.

ABSTRACT: The mechanistic target of rapamycin (MTOR) pathway regulates cell growth, energy homeostasis, apoptosis, and immune response. The regulatory associated protein of MTOR encoded by the RPTOR gene is a key component of this pathway. A previous survey of candidate genes found that RPTOR contains multiple SNPs with strong correlations between allele frequencies and climate variables, consistent with the action of selective pressures that vary across environments. Using data from a recent genome scan for selection signals, we honed in on a SNP (rs11868112) 26 kb upstream to the transcription start site of RPTOR that exhibits the strongest association with temperature variables. Transcription factor motif scanning and mining of recently mapped transcription factor binding sites identified a bindi

SUBMITTER: Sun C 

PROVIDER: S-EPMC2965758 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature