Substitution of nevirapine because of efavirenz toxicity in AIDS clinical trials group A5095.
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ABSTRACT:
SUBMITTER: Schouten JT
PROVIDER: S-EPMC2975665 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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Substitution of nevirapine because of efavirenz toxicity in AIDS clinical trials group A5095.
Schouten Jeffrey T JT Krambrink Amy A Ribaudo Heather J HJ Kmack Anne A Webb Nancy N Shikuma Cecilia C Kuritzkes Daniel R DR Gulick Roy M RM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100301 5
In AIDS Clinical Trials Group A5095, 9% of participants who experienced an adverse event related to efavirenz substituted nevirapine. Most adverse events resolved; 15 participants ultimately discontinued nevirapine therapy. Grade 3/4 hepatotoxicity was observed in 14% of individuals who substituted nevirapine, compared with 6% who continued efavirenz therapy. Substitution of nevirapine because of efavirenz toxicity was generally safe and efficacious. Clinical trials registration. NCT00013520 . ...[more]
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