Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats.

ABSTRACT:

Objective

Fluorophore-labeled contrast imaging agents are moving toward clinical use for a number of applications. The near-infrared dye IRDye 800CW is frequently used in its N-hydroxysuccinamide (NHS) ester form for labeling these agents. Following conjugation or breakdown of a labeled ligand, excess NHS ester is converted to the carboxylate form. To prepare for clinical use as a near-infrared fluorophore, a toxicity study was conducted on IRDye 800CW carboxylate.

Methods

Male and female Sprague-Dawley rats were given a single intravenous or intradermal administration of IRDye 800CW carboxylate; Indocyanine Green was used as a comparative control. Animals were injected with varying doses of the test and control articles and observed for up to 14 days. Clinical chemistry, he

SUBMITTER: Marshall MV 

PROVIDER: S-EPMC2978892 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature