Gemcitabine with carboplatin for advanced biliary tract cancers: a phase II single institution study.

ABSTRACT:

Background

Only recently has a standard chemotherapy regimen, gemcitabine plus cisplatin, been established for advanced biliary tract cancers (BTCs) based on a phase III randomized study. The aim of this phase II single-institution trial was to assess the efficacy and safety of gemcitabine combined with carboplatin in the first-line treatment of patients with advanced BTCs.

Methods

Patients with histologically proven BTCs, including cholangiocarcinoma or gallbladder and ampullary carcinomas, were treated with a maximum of nine cycles of intravenous (i.v.) gemcitabine at 1000 mg/m(2) over 30 min on days 1 and 8 with i.v. carboplatin dosed at an area-under-the-curve (AUC) of 5 over 60 min on day 1 of a 21-day cycle.

Results

A total of 48 patients with advanced BTCs (35

SUBMITTER: Williams KJ 

PROVIDER: S-EPMC3028583 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature