Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats.

ABSTRACT:

Background

The aim of this study is to clarify the neural mechanisms underlying orofacial pain abnormalities after cervical spinal nerve injury. Nocifensive behavior, phosphorylated extracellular signal-regulated kinase (pERK) expression and astroglial cell activation in the trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal dorsal horn (C1-C2) neurons were analyzed in rats with upper cervical spinal nerve transection (CNX).

Results

The head withdrawal threshold to mechanical stimulation of the lateral facial skin and head withdrawal latency to heating of the lateral facial skin were significantly lower and shorter respectively in CNX rats compared to Sham rats. These nocifensive effects were apparent within 1 day after CNX and lasted for more than 21 days.

SUBMITTER: Kobayashi A 

PROVIDER: S-EPMC3048571 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature