The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.

ABSTRACT: One of the greatest challenges in biomedicine is to define the critical targets and network interactions that are subverted to elicit growth deregulation in human cells. Understanding and developing rational treatments for cancer requires a definition of the key molecular targets and how they interact to elicit the complex growth deregulation phenotype. Viral proteins provide discerning and powerful probes to understand both how cells work and how they can be manipulated using a minimal number of components. The small DNA viruses have evolved to target inherent weaknesses in cellular protein interaction networks to hijack the cellular DNA and protein replication machinery. In the battle to escape the inevitability of senescence and programmed cell death, cancers have converged on similar m

SUBMITTER: Ou HD 

PROVIDER: S-EPMC3053133 | biostudies-literature | 2011 Jan-Feb

REPOSITORIES: biostudies-literature