Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.

ABSTRACT:

Context

Single-nucleotide polymorphisms (SNPs) in the SHBG gene are associated with type 2 diabetes mellitus. SHBG has also been proposed as a candidate gene for the polycystic ovary syndrome (PCOS).

Objective

The study aims were 1) to determine whether any of four SHBG SNPs (rs1779941, rs6297, rs6259, and rs727428) are associated with PCOS and 2) to determine whether SNP genotype influences SHBG levels in PCOS women.

Design

Using the transmission disequilibrium test, evidence of associations between SHBG SNPs and PCOS were analyzed. Additionally, correlations between SHBG levels and SNP genotype, body mass index, non-SHBG-bound testosterone, and insulin resistance estimated by the homeostasis model were determined.

Setting

The study was conducted at academic m

SUBMITTER: Wickham EP 

PROVIDER: S-EPMC3070246 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature