Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy.

ABSTRACT:

Background

Metabolomics, the comprehensive profile of small-molecule metabolites found in biological specimens, has the potential to provide insights into the pathogenesis of disease states and lead to the identification of new biomarkers.

Methods and results

We analysed 451 plasma metabolites by liquid chromatography/mass spectroscopy and gas chromatography/mass spectroscopy in 39 patients with primary dilated cardiomyopathy (DCM) and 31 age-, sex- and body mass index-matched controls. Sixty-one metabolites were significantly different between primary DCM and control individuals [false discovery rate (FDR) < 0·05]. Plasma levels of steroid metabolites, glutamine, threonine and histidine were reduced while levels of citric acid cycle intermediates and lipid β-oxidation produ

SUBMITTER: Alexander D 

PROVIDER: S-EPMC3071865 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature