Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules.

ABSTRACT:

Purpose of review

The molecular and cellular mechanisms that underlie allorecognition of MHC class II molecules have been the subject of much debate and experimentation in recent decades. In this review, we discuss several aspects of MHC class II structure, peptide acquisition and TcR-MHC-peptide interactions that have particular relevance to recognition of cells bearing allogeneic class II molecules.

Recent findings

First, MHC polymorphism is heavily biased toward those amino acids that influence stable peptide binding by MHC class II. Second, the peptide repertoire presented by class II molecules is highly diverse and can be edited substantially by the molecular catalyst HLA-DM and by tissue-specific expression of HLA-DO, stress and cytokines. Third, T-cell receptor dockin

SUBMITTER: Leddon SA 

PROVIDER: S-EPMC3085167 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature