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Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.

ABSTRACT: A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence.

SUBMITTER: Harrison TJ 

PROVIDER: S-EPMC3092851 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.

Harrison Tyler J TJ   Ho Stephen S   Leighton James L JL  

Journal of the American Chemical Society 20110427 19

A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence. ...[more]

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