Ontology highlight
ABSTRACT:
SUBMITTER: Harada C
PROVIDER: S-EPMC3105320 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Nature communications 20110208
Glia, the support cells of the central nervous system, have recently attracted considerable attention both as mediators of neural cell survival and as sources of neural regeneration. To further elucidate the role of glial and neural cells in neurodegeneration, we generated TrkB(GFAP) and TrkB(c-kit) knockout mice in which TrkB, a receptor for brain-derived neurotrophic factor (BDNF), is deleted in retinal glia or inner retinal neurons, respectively. Here, we show that the extent of glutamate-ind ...[more]