Ontology highlight
ABSTRACT:
SUBMITTER: Ghoreschi K
PROVIDER: S-EPMC3108066 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Ghoreschi Kamran K Laurence Arian A Yang Xiang-Ping XP Tato Cristina M CM McGeachy Mandy J MJ Konkel Joanne E JE Ramos Haydeé L HL Wei Lai L Davidson Todd S TS Bouladoux Nicolas N Grainger John R JR Chen Qian Q Kanno Yuka Y Watford Wendy T WT Sun Hong-Wei HW Eberl Gérard G Shevach Ethan M EM Belkaid Yasmine Y Cua Daniel J DJ Chen Wanjun W O'Shea John J JJ
Nature 20101001 7318
CD4(+) T-helper cells that selectively produce interleukin (IL)-17 (T(H)17), are critical for host defence and autoimmunity. Although crucial for T(H)17 cells in vivo, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been proposed to be the factors responsible for initiating specification. Here we show that T(H)17 differentiation can occur in the absence of TGF-β signalling. Neither IL-6 nor IL-23 alone efficient ...[more]