TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons.

ABSTRACT: Members of the transforming growth factor (TGF)-β family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance. This clearly created some discrepancies in the field with some studies favouring neuronal differentiation/survival of progenitors and others favouring cell cycle exit and neural stem cell quiescence/maintenance. Here, we provide a unifying hypothesis claiming that through its regulation of neural progenitor cell (NPC) proliferation, TGF-β signalling might be responsible for (i) maintaining stem cells in a quiescent stage, and (ii) promoting survival of newly generated neurons and their functional differentiation. Therefore, we performed a d

SUBMITTER: Kandasamy M 

PROVIDER: S-EPMC4124027 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature