Ontology highlight
ABSTRACT:
SUBMITTER: Abdel-Hamid H
PROVIDER: S-EPMC3115090 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Abdel-Hamid Huda H Chin Kimberley K Shahinas Dea D Moeder Wolfgang W Yoshioka Keiko K
Plant signaling & behavior 20100901 9
Recently we have reported that the αC-helix in the cyclic nucleotide binding domain (CNBD) is required for channel regulation and function of cyclic nucleotide gated ion channels (CNGCs) in Arabidopsis. A mutation at arginine 557 to cysteine (R557C) in the αC-helix of the CNBD caused an alteration in channel regulation. Protein sequence alignments revealed that R557 is located in a region that is important for calmodulin (CaM) binding. It has been hypothesized that CaM negatively regulates plant ...[more]