Continued stabilization of the nuclear higher-order structure of post-mitotic neurons in vivo.

ABSTRACT:

Background

Cellular terminal differentiation (TD) correlates with a permanent exit from the cell cycle and so TD cells become stably post-mitotic. However, TD cells express the molecular machinery necessary for cell proliferation that can be reactivated by experimental manipulation, yet it has not been reported the stable proliferation of any type of reactivated TD cells. Neurons become post-mitotic after leaving the ventricular zone. When neurons are forced to reenter the cell cycle they invariably undergo cell death. Wider evidence indicates that the post-mitotic state cannot solely depend on gene products acting in trans, otherwise mutations in the corresponding genes may lead to reentry and completion of the cell cycle in TD cells, but this has not been observed. In the interph

SUBMITTER: Alva-Medina J 

PROVIDER: S-EPMC3121788 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature