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First cases of microsporidiosis in transplant recipients in Spain and review of the literature.

ABSTRACT: Microsporidia are currently considered emerging pathogens responsible for life-threatening infections in organ transplant recipients. Here, we describe the first cases of intestinal microsporidiosis by Enterocytozoon bieneusi genotype D in two non-HIV-infected renal transplant recipients from Spain. Previously reported cases of microsporidiosis in organ transplant recipients have also been reviewed, highlighting the necessity of considering organ transplant recipients a risk group for microsporidiosis. A systematic search for these parasites is recommended in cases of persistent diarrhea and in the differential diagnosis of other syndromes, such as chronic fever of unknown etiology.

SUBMITTER: Galvan AL

PROVIDER: S-EPMC3122787 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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First cases of microsporidiosis in transplant recipients in Spain and review of the literature.

Galván A L AL Sánchez A M Martín AM Valentín M A Pérez MA Henriques-Gil N N Izquierdo F F Fenoy S S del Aguila C C

Journal of clinical microbiology 20110216 4

Microsporidia are currently considered emerging pathogens responsible for life-threatening infections in organ transplant recipients. Here, we describe the first cases of intestinal microsporidiosis by Enterocytozoon bieneusi genotype D in two non-HIV-infected renal transplant recipients from Spain. Previously reported cases of microsporidiosis in organ transplant recipients have also been reviewed, highlighting the necessity of considering organ transplant recipients a risk group for microspori ...[more]

PMID: 21325545

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Mucormycosis in renal transplant recipients: review of 174 reported cases.

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| S-EPMC5395857 | biostudies-other

Effects of Parvovirus B19 Infection in Renal Transplant Recipients: A Retrospective Review of Three Cases.

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Fumagillin Shortage: How to Treat <i>Enterocytozoon bieneusi</i> Microsporidiosis in Solid Organ Transplant Recipients in 2024?

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Kidney transplant recipients

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-15 | GSE250536 | GEO

Kidney transplant recipients

Project description:Kidney transplant recipients

| PRJNA1054489 | ENA

Impact of antiretroviral therapy on clinical outcomes in HIV <sup>+</sup> kidney transplant recipients: Review of 58 cases.

Project description:Background: Antiretroviral therapy (ART) poses challenging drug-drug interactions with immunosuppressant agents in transplant recipients. We aimed to determine the impact of specific antiretroviral regimens in clinical outcomes of HIV + kidney transplant recipients. Methods: A single-center, retrospective cohort study was conducted at a large academic center. Subjects included 58 HIV - to HIV + adult, first-time kidney transplant patients. The main intervention was ART regimen used after transplantation. The main outcomes assessed at one- and three-years were: patient survival, death-censored graft survival, and biopsy-proven acute rejection; we also assessed serious infections within the first six months post-transplant. Results: Patient and graft survival at three years were both 90% for the entire cohort. Patients receiving protease inhibitor (PI)-containing regimens had lower patient survival at one and three years than patients receiving PI-sparing regimens: 85% vs. 100% ( p=0.06) and 82% vs. 100% ( p=0.03), respectively. Patients who received PI-containing regimens had twelve times higher odds of death at 3 years compared to patients who were not exposed to PIs (odds ratio, 12.05; 95% confidence interval, 1.31-1602; p=0.02). Three-year death-censored graft survival was lower in patients receiving PI vs. patients on PI-sparing regimens (82 vs 100%, p=0.03). Patients receiving integrase strand transfer inhibitors-containing regimens had higher 3-year graft survival. There were no differences in the incidence of acute rejection by ART regimen. Individuals receiving PIs had a higher incidence of serious infections compared to those on PI-sparing regimens (39 vs. 8%, p=0.01). Conclusions: PI-containing ART regimens are associated with adverse outcomes in HIV + kidney transplant recipients.

| S-EPMC5310378 | biostudies-literature

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