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Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus.

ABSTRACT: A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

SUBMITTER: Pan D 

PROVIDER: S-EPMC3124378 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus.

Pan Dipanjan D   Caruthers Shelton D SD   Senpan Angana A   Yalaz Ceren C   Stacy Allen J AJ   Hu Grace G   Marsh Jon N JN   Gaffney Patrick J PJ   Wickline Samuel A SA   Lanza Gregory M GM  

Journal of the American Chemical Society 20110526 24

A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo. ...[more]

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