Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma.

ABSTRACT:

Purpose

Vaccination with hybridoma-derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induces follicular lymphoma (FL) -specific immune responses. To determine the clinical benefit of this vaccine, we conducted a double-blind multicenter controlled phase III trial.

Patients and methods

Treatment-naive patients with advanced stage FL achieving complete response (CR) or CR unconfirmed (CRu) after chemotherapy were randomly assigned two to one to receive either Id vaccine (Id-KLH + GM-CSF) or control (KLH + GM-CSF). Primary efficacy end points were disease-free survival (DFS) for all randomly assigned patients and DFS for randomly assigned patients

SUBMITTER: Schuster SJ 

PROVIDER: S-EPMC3139394 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature