Ontology highlight
ABSTRACT:
SUBMITTER: Xue J
PROVIDER: S-EPMC3150472 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20110501 5
Nonenzymatic protein glycation results in the formation of advanced glycation end products (AGEs) that are implicated in the pathology of diabetes, chronic inflammation, Alzheimer's disease, and cancer. AGEs mediate their effects primarily through a receptor-dependent pathway in which AGEs bind to a specific cell surface associated receptor, the Receptor for AGEs (RAGE). N(ɛ)-carboxy-methyl-lysine (CML) and N(ɛ)-carboxy-ethyl-lysine (CEL), constitute two of the major AGE structures found in tiss ...[more]