Factors affecting brain structure in men with HIV disease in the post-HAART era.

ABSTRACT:

Introduction

The purpose of this study was to characterize brain volumetric differences in HIV seropositive and seronegative men and to determine effects of age, cardiovascular risk, and HIV infection on structural integrity.

Methods

Magnetic resonance imaging was used to acquire high-resolution neuroanatomic data in 160 men aged 50 years and over, including 84 HIV seropositive and 76 seronegative controls. Voxel-based morphometry was used to derive volumetric measurements at the level of the individual voxel. Data from a detailed neuropsychological test battery were recombined into four summary scores representing psychomotor speed, visual memory, verbal memory, and verbal fluency.

Results

Both age and HIV status had a significant effect on both gray matter (GM) and

SUBMITTER: Becker JT 

PROVIDER: S-EPMC3154580 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature