A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols.

ABSTRACT: A metallo-β-lactamase-type alkylsulfatase was found to catalyze the enantioselective hydrolysis of sec-alkylsulfates with strict inversion of configuration. This catalytic event, which does not have an analog in chemocatalysis, yields homochiral (S)-configurated alcohols and nonreacted sulfate esters. The latter could be converted into (S)-sec-alcohols as the sole product in up to >99% ee via a chemoenzymatic deracemization protocol on a preparative scale.

SUBMITTER: Schober M 

PROVIDER: S-EPMC3155277 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature