T-cell Epitopes Identified by BALB/c Mice Immunized with Vaccinia Expressing HIV-1 Gag lie within immunodominant Regions Recognized by HIV-infected Indian Patients.

ABSTRACT:

Background

Human immunodeficiency virus (HIV) antigens from transmitted strains of HIV would prove crucial in vaccine designing for prevention of HIV infection. Immune response generated by Vaccinia construct expressing the HIV-1 gag gene from transmitted Indian HIV-1 subtype C strain (Vgag) in BALB/c mice is reported in the present study along with the identification of epitopes responsible for induction of the immune response.

Aims

The aim of this study was to determine immune response generated by the constructs in a mouse model and to understand the epitope specificities of the response.

Settings and design

This was an observational study carried out in BALB/c mice.

Materials and methods

The immunogenecity of Vgag construct was evaluated in BALB/c mice afte

SUBMITTER: Shete AV 

PROVIDER: S-EPMC3162811 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature