Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis.

ABSTRACT:

Rationale

Obstructive sleep apnea, which is characterized by intermittent hypoxia (IH) during sleep, has emerged as an independent risk factor for cardiovascular disease, including atherosclerosis. Leukotriene B4 (LTB4) production is increased in patients with obstructive sleep apnea and negatively correlates to hypoxic levels during sleep, with continuous positive airway pressure therapy decreasing LTB4 production.

Objectives

Determine the potential role of LTB4 in IH-induced atherosclerosis in a monocyte cellular model and a murine model.

Methods

THP-1 cells were exposed to IH for 3, 6, 24, and 48 hours. Macrophage transformation and foam cell formation were assessed after IH exposures. Apolipopotein E (ApoE)(-/-) or BLT1(-/-)/ApoE(-/-) mice were fed an atherogenic

SUBMITTER: Li RC 

PROVIDER: S-EPMC3172891 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature