A systems biology approach sheds new light on Escherichia coli acid resistance.

ABSTRACT: In order to develop an infection, diarrhogenic Escherichia coli has to pass through the stomach, where the pH can be as low as 1. Mechanisms that enable E. coli to survive in low pH are thus potentially relevant for pathogenicity. Four acid response systems involved in reducing the concentration of intracellular protons have been identified so far. However, it is still unclear to what extent the regulation of other important cellular functions may be required for survival in acid conditions. Here, we have combined molecular and phenotypic analysis of wild-type and mutant strains with computational network inference to identify molecular pathways underlying E. coli response to mild and strong acid conditions. The interpretative model we have developed led to the hypothesis that a complex tr

SUBMITTER: Stincone A 

PROVIDER: S-EPMC3177180 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature