Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3193408 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chen Jiekai J Liu Jing J Yang Jiaqi J Chen You Y Chen Jing J Ni Su S Song Hong H Zeng Lingwen L Ding Ke K Ding Ke K Pei Duanqing D
Cell research 20101207 1
Generation of induced pluripotent stem cells by defined factors has become a useful model to investigate the mechanism of reprogramming and cell fate determination. However, the precise mechanism of factor-based reprogramming remains unclear. Here, we show that Klf4 mainly acts at the initial phase of reprogramming to initiate mesenchymal-to-epithelial transition and can be functionally replaced by bone morphogenetic proteins (BMPs). BMPs boosted the efficiency of Oct4/Sox2-mediated reprogrammin ...[more]