Heterochronic evolution reveals modular timing changes in budding yeast transcriptomes.

ABSTRACT:

Background

Gene expression is a dynamic trait, and the evolution of gene regulation can dramatically alter the timing of gene expression without greatly affecting mean expression levels. Moreover, modules of co-regulated genes may exhibit coordinated shifts in expression timing patterns during evolutionary divergence. Here, we examined transcriptome evolution in the dynamical context of the budding yeast cell-division cycle, to investigate the extent of divergence in expression timing and the regulatory architecture underlying timing evolution.

Results

Using a custom microarray platform, we obtained 378 measurements for 6,263 genes over 18 timepoints of the cell-division cycle in nine strains of S. cerevisiae and one strain of S. paradoxus. Most genes show significant diverg

SUBMITTER: Simola DF 

PROVIDER: S-EPMC3218661 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature