Ontology highlight
ABSTRACT:
SUBMITTER: Rogers AN
PROVIDER: S-EPMC3220185 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Cell metabolism 20110701 1
Reducing protein synthesis slows growth and development but can increase adult life span. We demonstrate that knockdown of eukaryotic translation initiation factor 4G (eIF4G), which is downregulated during starvation and dauer state, results in differential translation of genes important for growth and longevity in C. elegans. Genome-wide mRNA translation state analysis showed that inhibition of IFG-1, the C. elegans ortholog of eIF4G, results in a relative increase in ribosomal loading and tran ...[more]