Human neutrophil peptide in lung chronic allograft dysfunction.
Ontology highlight
ABSTRACT: Context
Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients.Objective
To prospectively validate HNP as a biomarker for BOS.Materials and methods
HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients.Results
The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p = 0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time.Conclusion
HNP levels are elevated early and persistently in those that develop BOS.
SUBMITTER: Reilly C
PROVIDER: S-EPMC3222782 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Human neutrophil peptide in lung chronic allograft dysfunction.
Reilly Cavan C Cervenka Tereza T Hertz Marshall I MI Becker Trisha T Wendt Chris H CH
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20111011 8
<h4>Context</h4>Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients.<h4>Objective</h4>To prospectively validate HNP as a biomarker for BOS.<h4>Materials and methods</h4>HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients.<h4>Results</h4>The first HNP measurement after reaching baseline pulmonary function was predictive of developing BO ...[more]
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