Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis.

ABSTRACT:

Introduction

Variation in the CHRNA5-A3-B4 gene cluster is a promising candidate region for smoking behavior and has been linked to multiple smoking-related phenotypes (e.g., nicotine dependence) and diseases (e.g., lung cancer). Two single nucleotide polymorphisms (SNPs), rs16969968 in CHRNA5 and rs1051730 in CHRNA3, have generated particular interest.

Methods

We evaluated the published evidence for association between rs16969968 (k = 27 samples) and rs1051730 (k = 44 samples) SNPs with heaviness of smoking using meta-analytic techniques. We explored which SNP provided a stronger genetic signal and investigated study-level characteristics (i.e., ancestry, disease state) to establish whether the strength of association differed across populations. We additionally tested for

SUBMITTER: Ware JJ 

PROVIDER: S-EPMC3223575 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature